DSIP was discovered fifty years ago while searching for a "sleep substance" in the blood. Its name promises much; research, however, remains cautious. This guide explains what DSIP is, what studies have actually shown, its status, and how to store it in the laboratory.
DSIP 5 mg – €49.90All Neuro & Sleep Peptides
The essentials
A Swiss discovery from 1974
In Basel, the team of Marcel Monnier and Guido Schoenenberger investigated whether sleep could be transmitted through the blood. The researchers collected cerebral venous blood from rabbits induced into deep sleep by electrical stimulation of the thalamus, then injected it into other animals: the activitydeltaTheir electroencephalogram showed an increase in the slow-wave sleep stage associated with deep sleep. The responsible peptide was purified, and its sequence was published in 1977.
The molecule
| Characteristic | Value |
|---|---|
| CharacteristicSequence | ValueTrp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE) |
| CharacteristicSize | Value9 amino acids (nonapeptide) |
| CharacteristicCAS NO. | Value62568-57-4 |
| CharacteristicRaw formula | ValueC35H48N10O15 |
| CharacteristicMolar mass | Value848.8 g/mol |
| CharacteristicOther names | Valueemideltide (INN), delta sleep-inducing peptide |
DSIP has two distinctive features that make it an open subject: no specific receptor has been found, and the gene that codes for it has not been definitively identified. Therefore, its precise mechanism of action is not yet fully understood.
What the studies say
- In animalsInitial studies show an increase in slow-wave sleep, but the effect varies depending on the species, the dose, and the timing of administration. Several teams have not replicated the initial results.
- In humansSmall clinical studies from the 1980s gave mixed results on sleep. No large controlled trial has confirmed any effect.
- Other axesThe publications also cover the stress response, hormonal regulation, and body temperature.
DSIP is therefore not a proven "peptide sleep aid." It is a compound of basic research, interesting precisely because its mechanism of action remains unexplained.
Status: a research peptide
| Question | Response by 01/11/2026 |
|---|---|
| QuestionIs DSIP an authorized drug? | Response by 01/11/2026No, neither in France nor in the European Union. |
| QuestionIn what form is it sold? | Response by 01/11/2026In lyophilized powder form, as a research reagent, without medical use. |
| QuestionDoes it have an official name? | Response by 01/11/2026Yes: emideltide, its international common name. |
Laboratory storage
| State | Où | Approximate duration |
|---|---|---|
| StateLyophilized powder, sealed bottle | OùRefrigerator (2 to 8 °C) or freezer (−20 °C), away from light | Approximate durationSeveral months |
| StateLyophilized powder, transport | OùRoom temperature | Approximate durationA few days |
| StateReconstituted with bacteriostatic water | OùRefrigerator (2 to 8 °C), never in the freezer | Approximate durationUp to 28 days |
Like all lyophilized peptides, DSIP is reconstituted withbacteriostatic water, added slowly against the side of the bottle. The complete method is described inreconstitute a lyophilized peptide.
The DSIP at PeptiLine
| Product | Content | Price | Analysis |
|---|---|---|---|
| ProductDSIP 5 mg | Content5 mg vial, lyophilized powder | Price49,90 € | AnalysisBatch HPLC; report not published online for this product |
We only publish purity values when the Janoshik report is online: this is not yet the case for DSIP, so the entry does not display any figures. Published reports for other peptides are on the pagecertificates of analysis.
Frequently Asked Questions
What is DSIP?
DSIP (Delta Sleep-Inducing Peptide, or emideltide) is a 9-amino-acid peptide described in 1974 in Basel. It was isolated in animals during deep sleep, hence its name "delta sleep-inducing peptide".
Does the DSIP make you sleepy?
This has not been proven. Early animal studies showed an increase in deep sleep, but these were not always replicated, and small human studies in the 1980s gave mixed results.
Is DSIP a medication?
No. It is not authorized as a medicine in France or the European Union. It is sold as a research peptide, in lyophilized powder form.
What is the price of DSIP?
At PeptiLine, the 5mg vial costs €49.90. Delivery is €10, free for orders over €160, with dispatch within 24 to 48 hours from France.
How to keep the DSIP
In powder form, store in the refrigerator or freezer, away from light. Once reconstituted with bacteriostatic water, refrigerate for up to 28 days, never freeze.
- DSIP: the guide— discovery, state of sleep research, conservation (you are here)
- Selank and Semax— Two Russian heptapeptides compared, Janoshik analysis
- Bacteriostatic water— the reconstitution solvent explained
- Reconstitute a lyophilized peptide— the step-by-step manipulation in the laboratory
- Neuro & Sleep— all peptides in the category
- Certificates of analysis— all the Janoshik reports, with their key
Monnier M., Schoenenberger G. A. et al., 1974-1977 (Basel); PubChem CID 68816; status as of 01/11/2026. PeptiLine products are intended exclusively for scientific laboratory research. This page does not provide medical advice, protocols, or dosage information.