Almost all of our proteins are encoded by nuclear DNA. MOTS-c is an exception: it is encoded in the small mitochondrial genome. Its discovery in 2015 opened up a field of research on how mitochondria "communicate" with the rest of the cell. Here's what it is, what studies show, and how to choose between 10 and 40 mg.
MOTS-c 10 mg – €49.90MOTS-c 40 mg – €99.90
The essentials
A peptide originating from the mitochondria
Its name sums up its origin:Mitochondrial Open reading frame of the Twelve S rRNA type-cIts sequence is hidden in the 12S ribosomal RNA gene of mitochondrial DNA. MOTS-c belongs to the family ofmitochondria-derived peptides, like humanin.
| Characteristic | Value |
|---|---|
| CharacteristicSequence | ValueMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR) |
| CharacteristicSize | Value16 amino acids |
| CharacteristicCAS NO. | Value1627580-64-6 |
| CharacteristicRaw formula | ValueC101H152N28O22S2 |
| CharacteristicMolar mass | Value2,174.6 g/mol |
What the studies say
- The discovery (Lee et al.,Cell Metabolism, 2015)In mice, MOTS-c activates the AMPK pathway, the cell's "energy sensor", and has limited weight gain and insulin resistance under a high-fat diet.
- The core (Kim et al.,Cell Metabolism, 2018)In situations of metabolic stress, MOTS-c migrates to the nucleus and modifies gene expression there. This is an example of a signal sent by the mitochondria to the nucleus.
- The exercise (Reynolds et al.,Nature Communications, 2021): its level increases during exercise in humans, and its administration has improved the physical performance of aged mice.
These results come primarily from animal studies. They make MOTS-c a major topic in research on metabolism and aging, although it has no medical application to date.
Status
No MOTS-c-based medication is authorized, in France or elsewhere. It is sold as a research peptide, in lyophilized powder form.
10 mg or 40 mg?
| Format | Price | Price per mg | Report published |
|---|---|---|---|
| FormatMOTS-c 10 mg | Price49,90 € | Price per mg4,99 € | Report publishedNo |
| FormatMOTS-c 40 mg | Price99,90 € | Price per mg2,50 € | Report published#223450 |
The 40 mg dose is half the price per milligram. However, once reconstituted, a vial can only be kept for a maximum of 28 days in the refrigerator, regardless of its size: the correct format is the one that the experiment will use within that timeframe.
Our Janoshik analysis
| Report | Product | Batch | Analysis | Quantity measured | HPLC Purity | Key |
|---|---|---|---|---|---|---|
| Report#223450 | ProductMOTS-c 40 mg | BatchMP-777MS401 | Analysis25/08/2026 | Quantity measured44.07 mg | HPLC Purity99,55 % | KeyQ4LGP1B2VM8M |
The key can be verified at janoshik.com/verify. The report for the 10 mg product has not yet been published; therefore, its product page does not display any purity figures.
Conservation
| State | Où | Approximate duration |
|---|---|---|
| StateLyophilized powder, sealed bottle | OùRefrigerator (2 to 8 °C) or freezer (−20 °C), away from light | Approximate durationSeveral months |
| StateLyophilized powder, transport | OùRoom temperature | Approximate durationA few days |
| StateReconstituted with bacteriostatic water | OùRefrigerator (2 to 8 °C), never in the freezer | Approximate durationUp to 28 days |
Reconstruction:bacteriostatic waterand detailed method inreconstitute a lyophilized peptideFor another player in cellular metabolism, see theNAD+ guide.
Frequently Asked Questions
What is MOTS-c?
A 16-amino-acid peptide encoded by mitochondrial DNA, not nuclear DNA. Described in 2015, it is being studied for its role in glucose and fat metabolism.
How does MOTS-c work?
In mice, it activates the AMPK pathway, the cell's energy sensor. Under metabolic stress, it can also migrate into the nucleus and alter gene expression.
Is MOTS-c related to the exercise?
Yes: a 2021 study (Nature Communications) showed that its level increases during exercise in humans, and that its administration improved the performance of aged mice.
Should I choose MOTS-c 10 mg or 40 mg?
The 40 mg costs €2.50 per mg compared to €4.99 for the 10 mg, but a reconstituted vial can be kept for a maximum of 28 days: choose the format that the experiment will use within this timeframe.
Is the PeptiLine MOTS-c analyzed?
Yes. Batch MP-777MS401 of the 40 mg product was measured by Janoshik at 44.07 mg and 99.55% purity (report #223450). The report for the 10 mg product has not yet been published.
- WORDS-c: the guide— the peptide encoded by mitochondrial DNA (you are here)
- NAD+ Guide— the coenzyme of cellular metabolism
- Bacteriostatic water— the reconstitution solvent explained
- Reconstitute a lyophilized peptide— the step-by-step manipulation in the laboratory
- Longevity & Energy— all peptides in the category
- Certificates of analysis— all the Janoshik reports, with their key
Lee C. et al., Cell Metabolism, 2015; Kim K. H. et al., Cell Metabolism, 2018; Reynolds J. C. et al., Nature Communications, 2021; PubChem CID 146675088; Janoshik report #223450. PeptiLine products are intended for scientific laboratory research use only. This page does not provide medical advice, protocols, or dosage information.