IGF-1 LR3 1 mg — long-acting analogue of IGF-1
L’IGF-1 LR3(Long R3 IGF-1) is arecombinant analog of IGF-1of 83 amino acids (~9,111 Da), designed to evade IGFBP-binding proteins. Bottle of1 mg lyophilizedintendedexclusively for laboratory research.
Product features
- Compound :IGF-1 LR3, IGF-1 with an N-terminal extension of 13 amino acids and arginine at position 3
- Quantity :1 mg per vial, lyophilized
- Molecular weight:approximately 9,111 Da
- Presentation :sealed bottle, crimped cap, white lyophilized powder
Scientific context
Native IGF-1 is largely captured by theIGFBPwhich limit its activity. The two modifications to LR3 reduce this bond: its half-life is reduced to approximately20 to 30 hoursIt activates the receptorIGF-1Rand the roadsPI3K/Akt/mTOR et MAPK/ERK, which regulate cell proliferation and differentiation.
It is widely used incell culture(serum-free media) and studied in muscle cell proliferation and IGF-1R signaling models.
Reconstruction and conservation
The bottle contains a freeze-dried powder to be reconstituted withbacteriostatic waterAvailable separately, without shaking. Store the powder in a freezer away from light; reconstituted solution in a refrigerator, approximately 3 to 4 weeks. Avoid repeated freezing.
Delivery
Shipping within 24 to 48 hours from our stock in France.3 to 5 business dayswith follow-up.
What this product is not
IGF-1 LR3 issold here as a laboratory reagent, and nothing elseThis is notneither a medicine nor a food supplementHe is notnot intended for human or veterinary useThis product is not intended for diagnostic or therapeutic use, and no instructions for use, dosage, or administration protocol are provided. The buyer is solely responsible for complying with applicable regulations in their country.
Frequently Asked Questions
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid recombinant analog of IGF-1. It has a 13-amino-acid N-terminal extension and an arginine at position 3, which reduces its binding to IGFBP proteins.
What is the difference with native IGF-1?
Native IGF-1 is rapidly taken up by IGFBPs and its free half-life is a few minutes. LR3 binds to it much less readily: its half-life reaches approximately 20 to 30 hours and its activity in cell models is higher.
On what paths is he acting?
It activates the IGF-1 receptor (IGF-1R) and, downstream, the PI3K/Akt/mTOR and MAPK/ERK pathways, which regulate cell proliferation, differentiation, and survival.
In what form is it delivered?
In the form of a white lyophilized powder in a sealed 1 mg bottle, to be reconstituted with bacteriostatic water.
How is it stored?
The powder should be stored in the freezer, away from light; the reconstituted solution should be stored in the refrigerator for approximately 3 to 4 weeks. Do not shake the bottle.
What is this product intended for?
For scientific research in the laboratory only. It is not intended for human or animal consumption, nor for therapeutic use.
Product intended exclusively for scientific laboratory research. Not intended for human or animal consumption, nor for medical, veterinary, or therapeutic use. Sale strictly reserved for adults (18 years and older).
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