KPV 10 mg

KPV 10 mg — an anti-inflammatory tripeptide derived from α-MSH

Le KPVis asynthetic tripeptide(Lys-Pro-Val, ~342 g/mol) corresponding toC-terminal fragment of α-MSHThe melanin-stimulating hormone. It retains the anti-inflammatory properties of the parent hormone without its pigmentary effect. Bottle of10 mg lyophilizedintendedexclusively for laboratory research.

Product features

• Compound :KPV (Lys-Pro-Val), fragment 11-13 of the α-MSH
• Quantity :10 mg per vial, lyophilized
• Molecular weight:342.4 g/mol
• Presentation :sealed bottle, crimped cap, white lyophilized powder

Scientific context

In the models studied, the KPVinhibits the NF-κB pathwayand reduces the production of pro-inflammatory cytokines (TNF-α, IL-1β). It is handled by the carrierPepT1It targets intestinal epithelial and immune cells, making it a subject of study in colitis models. Its anti-inflammatory action does not involve the stimulation of melanocortin receptors, and antimicrobial activity has also been described.

It is being studied in models of intestinal and skin inflammation and wound healing. The data remain largely preclinical.

Reconstruction and conservation

The bottle contains a freeze-dried powder to be reconstituted withbacteriostatic waterAvailable separately. Store powder in a freezer away from light; reconstituted solution in a refrigerator, approximately 4 weeks. Avoid repeated freezing.

Delivery

Shipping within 24 to 48 hours from our stock in France.3 to 5 business dayswith follow-up.

What this product is not

The KPV issold here as a laboratory reagent, and nothing elseThis is notneither a medicine, nor a food supplement, nor a cosmetic productHe is notnot intended for human or veterinary useThis product is not intended for diagnostic or therapeutic use, and no instructions for use, dosage, or administration protocol are provided. The buyer is solely responsible for complying with applicable regulations in their country.

Frequently Asked Questions

What is KPV?
KPV is a tripeptide (Lysine-Proline-Valine) that corresponds to the C-terminal fragment of α-MSH. It is studied in research for its anti-inflammatory properties, without the pigmentary effect of the parent hormone.

How does it work?
In the models studied, KPV inhibits the NF-κB pathway and reduces the expression of pro-inflammatory cytokines such as TNF-α and IL-1β. It is transported into intestinal cells by the PepT1 transporter.

What is the difference with α-MSH?
α-MSH has 13 amino acids and stimulates pigmentation via melanocortin receptors. KPV retains only the last three: the anti-inflammatory effect is preserved, but not the pigmentary effect.

In what form is it delivered?
In the form of a white lyophilized powder in a sealed 10 mg bottle, to be reconstituted with bacteriostatic water.

How is it stored?
The powder can be stored in the freezer, away from light; the reconstituted solution can be stored in the refrigerator for approximately 4 weeks.

What is this product intended for?
For scientific research in the laboratory only. It is not intended for human or animal consumption, nor for therapeutic use.

Product intended exclusively for scientific laboratory research. Not intended for human or animal consumption, nor for medical, veterinary, or therapeutic use. Sale strictly reserved for adults (18 years and older).