PT-141 10 mg — melanocortin receptor agonist MC4R
Le PT-141, OrBremelanotideis asynthetic cyclic heptapeptidederived from Melanotan 2, of which it is the deamidated metabolite (~1025 g/mol). This small structural difference alters its profile: while MT-2 broadly activates melanocortin receptors, PT-141 focuses on theMC4Rand theMC3R, with weak action on the MC1R of melanocytes. Vial of10 mg lyophilizedintendedexclusively for laboratory research.
Product features
- Compound :PT-141 / Bremelanotide, cyclic analog of α-MSH
- Quantity :10 mg per vial, lyophilized
- Purity:99.96% measured by HPLC (Janoshik, report #229263)
- Quality control:Independent COA per batch
- Presentation :sealed bottle, crimped cap, white lyophilized powder
Scientific context
PT-141 is the first melanocortinic agonist to have been clinically studied for its actioncentralon sexual function, via a hypothalamic pathway independent of the vascular system. In published models, the activation ofMC4RThis is accompanied by the release of dopamine in the medial preoptic area. The receptorMC3RIt, in turn, plays a role in energy homeostasis and certain anti-inflammatory pathways.
It is thisrelative selectivityThis makes it a valuable research tool: it allows researchers to distinguish the central effects of melanocortins from their pigmentary effects. The data remain largely preclinical, and the published clinical results pertain to a pharmaceutical form that is not this product.
PT-141 and MT-2: same family, different profiles
Both references are in the catalog and share the same basic cyclic sequence. They differ on one crucial point, thereceptor selectivity :
- MT-2— C-terminal amide, agonistnon-selectiveMC1R, MC3R, MC4R. Stimulates melanogenesis.
- PT-141— free C-terminal acid, concentrated affinity onMC4R and MC3RNo significant pigmentation was observed in the models studied.
A protocol designed for one cannot be transposed to the other: the main target is not the same.
Reconstruction and conservation
The bottle contains a freeze-dried powder to be reconstituted withbacteriostatic water, available separately. Powder should be stored away from light; reconstituted solution should be stored in the refrigerator. Melanocortin analogues arelight-sensitive: limit the exposure of the reconstituted vial.
Quality and analysis
Each batch is analyzed byHPLCwith aIndependent Certificate of Analysis (COA)specific to the batch. The stated purity, 99.96%, is that of the certificate.
Delivery
Shipping within 24 to 48 hours from our stock in France.3 to 5 business days, with follow-up. Direct sale without intermediaries — that's what allows the advertised price.
What this product is not
The PT-141 issold here as a laboratory reagent, and nothing elseThis is notneither a medicine, nor a supplement, nor a product for sexual purposesIt does not have any marketing authorization in Europe for any human use whatsoever. It is notnot intended for human or veterinary useThis product is not intended for diagnostic or therapeutic use, and no instructions for use, dosage, or administration protocol are provided. The buyer is solely responsible for complying with applicable regulations in their country.
Frequently Asked Questions
What is the PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan 2, studied in research as an agonist of melanocortin receptors MC4R and MC3R.
What is the difference with the MT-2?
Selectivity. MT-2 is a non-selective agonist (MC1R, MC3R, MC4R) and stimulates melanogenesis; PT-141, its deamidated metabolite, has a concentrated affinity for MC4R and MC3R and does not induce significant pigmentation in published models.
Is the product analyzed?
Yes. Each batch is analyzed by HPLC (latest published report: 99.96%) and accompanied by an independent Certificate of Analysis (COA) specific to the batch.
In what form is it delivered?
In the form of a white lyophilized powder in a sealed 10 mg bottle, to be reconstituted with bacteriostatic water.
How is it stored?
The powder should be stored away from light, and the reconstituted solution in the refrigerator. Melanocortin analogues are sensitive to light.
What is this product intended for?
For scientific research in the laboratory only. It is not intended for human or animal consumption, nor for therapeutic use.
Product intended exclusively for scientific laboratory research. Not intended for human or animal consumption, nor for medical, veterinary, or therapeutic use. Sale strictly reserved for adults (18 years and older).
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