VIP 5 mg

VIP 5 mg — neuropeptide agonist of VPAC1 and VPAC2 receptors

Le VIP (Vasoactive Intestinal Peptide, intestinal vasoactive peptide) is aneuropeptide of 28 amino acids(~3,326 g/mol) of the secretin/glucagon family. It is expressed in the brain, intestine, lungs, and immune cells, where it acts as a neurotransmitter, vasodilator, and modulator of inflammation. Bottle of5 mg lyophilizedintendedexclusively for laboratory research.

Product features

• Compound :VIP, intestinal vasoactive peptide (28 amino acids, C-terminal amidated)
• Quantity :5 mg per vial, lyophilized
• Purity:98.6% measured by HPLC (Janoshik, lot MP-777VIP501)
• Quality control:Independent COA per batch, available for consultation on thecertificates page
• Presentation :sealed bottle, crimped cap, white lyophilized powder

Scientific context

VIP activates two G protein-coupled receptors,VPAC1 et VPAC2and weakly the receptorPAC1Their activation increases intracellular cAMP: relaxation of vascular, bronchial, and digestive smooth muscles, intestinal secretion of water and electrolytes, and orientation of lymphocytes towards an anti-inflammatory profile. In thesuprachiasmatic nucleusThe VIP/VPAC2 pair participates in the synchronization of the circadian clock.

Sa very short plasma half-life, on the order of a minute, is primarily a tool for studying VPAC receptors and neuro-immune communication. The data remain largely preclinical.

VIP and PACAP: two related peptides

• VIP— 28 amino acids, high affinity forVPAC1 and VPAC2, low for PAC1.
• PACAP— 27 or 38 amino acids, ~68% identity with VIP, active VPAC1, VPAC2and PAC1with a strong affinity.

Reconstruction and conservation

The bottle contains a freeze-dried powder to be reconstituted withbacteriostatic water, available separately. Powder should be stored in the freezer away from light; reconstituted solution in the refrigerator. The VIP contains aoxidation-sensitive methionine: close the bottle quickly and avoid repeated freezing.

Quality and analysis

The batch was analyzed by the independent laboratoryJanoshik : 4.88 mgdosed at 5 mg as advertised and with HPLC purity of98,6 %The complete certificate is published as is.

Delivery

Shipping within 24 to 48 hours from our stock in France.3 to 5 business days, with follow-up. Direct sale without intermediaries — that's what allows the advertised price.

What this product is not

The VIP issold here as a laboratory reagent, and nothing elseThis is notneither a medicine nor a food supplementHe is notnot intended for human or veterinary useThis product is not intended for diagnostic or therapeutic use, and no instructions for use, dosage, or administration protocol are provided. The buyer is solely responsible for complying with applicable regulations in their country.

Frequently Asked Questions

What is a VIP?
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide from the secretin/glucagon family, studied in research as an agonist of VPAC1 and VPAC2 receptors.

What is the difference with PACAP?
The two peptides share approximately 68% identity and activate both VPAC1 and VPAC2 receptors. PACAP also binds with high affinity to the PAC1 receptor, which VIP activates only weakly.

Is the product analyzed?
Yes. Batch MP-777VIP501 was analyzed by Janoshik: 4.88 mg measured and an HPLC purity of 98.6%. The Certificate of Analysis (COA) is published on our certificates page.

In what form is it delivered?
In the form of a white lyophilized powder in a sealed 5 mg bottle, to be reconstituted with bacteriostatic water.

How is it stored?
The powder should be stored in a freezer, protected from light; the reconstituted solution should be stored in a refrigerator. VIP contains a methionine that is sensitive to oxidation.

What is this product intended for?
For scientific research in the laboratory only. It is not intended for human or animal consumption, nor for therapeutic use.

Product intended exclusively for scientific laboratory research. Not intended for human or animal consumption, nor for medical, veterinary, or therapeutic use. Sale strictly reserved for adults (18 years and older).